Design, Synthesis and Preclinical Assessment of (99m)Tc-iFAP for In Vivo Fibroblast Activation Protein (FAP) Imaging

Fibroblast activation protein (FAP) is expressed in the microenvironment of most human epithelial tumors. (68)Ga-labeled FAP inhibitors based on the cyanopyrrolidine structure (FAPI) are currently used for the detection of the tumor microenvironment by PET imaging. This research aimed to design, syn...

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Detalles Bibliográficos
Autores principales: Trujillo-Benítez, Diana, Luna-Gutiérrez, Myrna, Ferro-Flores, Guillermina, Ocampo-García, Blanca, Santos-Cuevas, Clara, Bravo-Villegas, Gerardo, Morales-Ávila, Enrique, Cruz-Nova, Pedro, Díaz-Nieto, Lorenza, García-Quiroz, Janice, Azorín-Vega, Erika, Rosato, Antonio, Meléndez-Alafort, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746441/
https://www.ncbi.nlm.nih.gov/pubmed/35011496
http://dx.doi.org/10.3390/molecules27010264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746441/
https://www.ncbi.nlm.nih.gov/pubmed/35011496
http://dx.doi.org/10.3390/molecules27010264

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