Cargando…

Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation

A number of pyrrolo[2,3-c]pyridines, pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines were designed and synthesized as antiproliferative agents. The target compounds possessed selected substituents in analogous positions on the central scaffold that allowed the extraction of interesting SARs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dimitrakis, Spyridon, Gavriil, Efthymios-Spyridon, Pousias, Athanasios, Lougiakis, Nikolaos, Marakos, Panagiotis, Pouli, Nicole, Gioti, Katerina, Tenta, Roxane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746528/ https://www.ncbi.nlm.nih.gov/pubmed/35011476 http://dx.doi.org/10.3390/molecules27010247

Ejemplares similares

Discovery of a High Affinity Adenosine A(1)/A(3) Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-d]pyridazine Scaffold
por: Suchankova, Anna, et al.
Publicado: (2022)

Discovery of New 1,4,6-Trisubstituted-1H-pyrazolo[3,4-b]pyridines with Anti-Tumor Efficacy in Mouse Model of Breast Cancer †
por: Georgiou, Maria, et al.
Publicado: (2023)

Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues
por: Papadakis, Georgios, et al.
Publicado: (2020)

Purine and Purine Isostere Derivatives of Ferrocene: An Evaluation of ADME, Antitumor and Electrochemical Properties
por: Rep, Valentina, et al.
Publicado: (2020)

Screening of Heteroaromatic Scaffolds against Cystathionine Beta-Synthase Enables Identification of Substituted Pyrazolo[3,4-c]Pyridines as Potent and Selective Orthosteric Inhibitors
por: Fantel, Anna-Maria, et al.
Publicado: (2020)

Assessment of the Nutraceutical Effects of Oleuropein and the Cytotoxic Effects of Adriamycin, When Administered Alone and in Combination, in MG-63 Human Osteosarcoma Cells
por: Gioti, Katerina, et al.
Publicado: (2021)

Investigating the Spectrum of Biological Activity of Substituted Quinoline-2-Carboxamides and Their Isosteres (†)
por: Gonec, Tomas, et al.
Publicado: (2012)

Synthesis and Cytotoxic Activity of Some New 2,6-Substituted Purines
por: Kode, Nageswara Rao, et al.
Publicado: (2011)

Robust, universal biomarker assay to detect senescent cells in biological specimens
por: Evangelou, Konstantinos, et al.
Publicado: (2016)

Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values
por: Rząd, Kamila, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Resveratrol Methoxy Derivatives
por: Fragopoulou, Elizabeth, et al.
Publicado: (2023)

[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes
por: Epplin, Rachel C., et al.
Publicado: (2022)

Synthesis and Antimicrobial Activity of δ-Viniferin Analogues and Isosteres
por: Mattio, Luce Micaela, et al.
Publicado: (2021)

Expanding the limits of amide–triazole isosteric substitution in bisamide-based physical gels
por: Tautz, Markus, et al.
Publicado: (2019)

N-Edited Guanine Isosteres
por: Li, Xin, et al.
Publicado: (2023)

Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity
por: Rouchal, Michal, et al.
Publicado: (2021)

A Hydride‐Substituted Homoleptic Silylborate: How Similar is it to its Diborane(6)‐Dianion Isostere?
por: Gilmer, Jannik, et al.
Publicado: (2022)

Isosterism in pyrrole via azaboroles substitution, a theoretical investigation for electronic structural, stability and aromaticity
por: H. El-Demerdash, Safinaz, et al.
Publicado: (2023)

Frequency and isostericity of RNA base pairs
por: Stombaugh, Jesse, et al.
Publicado: (2009)

Isosteric substitution in cationic-amphiphilic polymers reveals an important role for hydrogen bonding in bacterial membrane interactions
por: Uppu, D. S. S. M., et al.
Publicado: (2016)

Context-sensitivity of isosteric substitutions of non-Watson–Crick basepairs in recurrent RNA 3D motifs
por: Khisamutdinov, Emil F, et al.
Publicado: (2021)

Structure Property Relationships of Carboxylic Acid Isosteres
por: Lassalas, Pierrik, et al.
Publicado: (2016)

Azacrown-calixpyrrole isosteres: receptors and sensors for anions
por: Sartori, Austin R., et al.
Publicado: (2023)

Synthesis, Biological Evaluation and Stability Studies of Some Novel Aza-Acridine Aminoderivatives
por: Karelou, Maria, et al.
Publicado: (2020)

Hydrogen-Bonding Interactions of 8-Substituted Purine Derivatives
por: Osifová, Zuzana, et al.
Publicado: (2023)

Adamantane-Substituted Purine Nucleosides: Synthesis, Host–Guest Complexes with β-Cyclodextrin and Biological Activity
por: Rudolfová, Jana, et al.
Publicado: (2022)

Hydrogen bonding abilities of hydroxamic acid and its isosteres
por: Kohli, Ruchi
Publicado: (2016)

Effect of heterocycle content on metal binding isostere coordination
por: Dick, Benjamin L., et al.
Publicado: (2020)

Aza- and Azo-Stilbenes: Bio-Isosteric Analogs of Resveratrol
por: Lizard, Gérard, et al.
Publicado: (2020)

Salicylate metal-binding isosteres as fragments for metalloenzyme inhibition
por: Jackl, Moritz K., et al.
Publicado: (2022)

Characterizing the Self-Assembly Properties of Monoolein Lipid Isosteres
por: Fracassi, Alessandro, et al.
Publicado: (2023)

Regioselective Diversification of 2,1-Borazaronaphthalenes: Unlocking Isosteric Space via C–H Activation
por: Davies, Geraint H. M., et al.
Publicado: (2017)

Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole
por: Juhás, Martin, et al.
Publicado: (2022)

Rhodium-Catalyzed B–H Activation of 1,2-Azaborines: Synthesis and Characterization of BN Isosteres of Stilbenes
por: Brown, Alec N., et al.
Publicado: (2014)

Equilibria and Isosteric Heat of Adsorption of Methane on Activated Carbons Derived from South African Coal Discards
por: Abdulsalam, Jibril, et al.
Publicado: (2020)

Recurrent structural RNA motifs, Isostericity Matrices and sequence alignments
por: Lescoute, Aurélie, et al.
Publicado: (2005)

Genetically Directed Production of Recombinant, Isosteric and Nonhydrolysable Ubiquitin Conjugates
por: Stanley, Mathew, et al.
Publicado: (2016)

Comparative chemical and biological hydrolytic stability of homologous esters and isosteres
por: de Souza, Hygor M. R., et al.
Publicado: (2022)

Correction: Effect of heterocycle content on metal binding isostere coordination
por: Dick, Benjamin L., et al.
Publicado: (2022)

Identified Isosteric Replacements of Ligands’ Glycosyl Domain by Data Mining
por: Zhang, Tinghao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_766sf9l4d8dr8j0vr55hprtmgq