New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2

A series of deoxycholic acid (DCA) amides containing benzyl ether groups on the steroid core were tested against the tyrosyl-DNA phosphodiesterase 1 (TDP1) and 2 (TDP2) enzymes. In addition, 1,2,4- and 1,3,4-oxadiazole derivatives were synthesized to study the linker influence between a para-bromoph...

Descripción completa

Detalles Bibliográficos
Autores principales: Salomatina, Oksana V., Dyrkheeva, Nadezhda S., Popadyuk, Irina I., Zakharenko, Alexandra L., Ilina, Ekaterina S., Komarova, Nina I., Reynisson, Jóhannes, Salakhutdinov, Nariman F., Lavrik, Olga I., Volcho, Konstantin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746696/
https://www.ncbi.nlm.nih.gov/pubmed/35011303
http://dx.doi.org/10.3390/molecules27010072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746696/
https://www.ncbi.nlm.nih.gov/pubmed/35011303
http://dx.doi.org/10.3390/molecules27010072

Ejemplares similares