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New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2

A series of deoxycholic acid (DCA) amides containing benzyl ether groups on the steroid core were tested against the tyrosyl-DNA phosphodiesterase 1 (TDP1) and 2 (TDP2) enzymes. In addition, 1,2,4- and 1,3,4-oxadiazole derivatives were synthesized to study the linker influence between a para-bromoph...

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Detalles Bibliográficos
Autores principales:	Salomatina, Oksana V., Dyrkheeva, Nadezhda S., Popadyuk, Irina I., Zakharenko, Alexandra L., Ilina, Ekaterina S., Komarova, Nina I., Reynisson, Jóhannes, Salakhutdinov, Nariman F., Lavrik, Olga I., Volcho, Konstantin P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746696/ https://www.ncbi.nlm.nih.gov/pubmed/35011303 http://dx.doi.org/10.3390/molecules27010072

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