Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α

Prolyl hydroxylase domain-containing protein 2 (PHD2) inhibition, which stabilizes hypoxia-inducible factor (HIF)-1α and thus triggers adaptation responses to hypoxia in cells, has become an important therapeutic target. Despite the proven high potency, small-molecule PHD2 inhibitors such as IOX2 ma...

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Detalles Bibliográficos
Autores principales: Jian, Cheng-Bang, Yu, Xu-En, Gao, Hua-De, Chen, Huai-An, Jheng, Ren-Hua, Chen, Chong-Yan, Lee, Hsien-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746909/
https://www.ncbi.nlm.nih.gov/pubmed/35010112
http://dx.doi.org/10.3390/nano12010163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746909/
https://www.ncbi.nlm.nih.gov/pubmed/35010112
http://dx.doi.org/10.3390/nano12010163

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