Synthesis, Pharmacological Evaluation, and Computational Studies of Cyclic Opioid Peptidomimetics Containing β(3)-Lysine

Our formerly described pentapeptide opioid analog Tyr-c[D-Lys-Phe-Phe-Asp]NH(2) (designated RP-170), showing high affinity for the mu (MOR) and kappa (KOR) opioid receptors, was much more stable than endomorphine-2 (EM-2) in the rat brain homogenate and displayed remarkable antinociceptive activity...

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Detalles Bibliográficos
Autores principales: Wtorek, Karol, Lipiński, Piotr F. J., Adamska-Bartłomiejczyk, Anna, Piekielna-Ciesielska, Justyna, Sukiennik, Jarosław, Kluczyk, Alicja, Janecka, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747000/
https://www.ncbi.nlm.nih.gov/pubmed/35011383
http://dx.doi.org/10.3390/molecules27010151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747000/
https://www.ncbi.nlm.nih.gov/pubmed/35011383
http://dx.doi.org/10.3390/molecules27010151

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