Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents

A series of eleven 4-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines were designed and synthesized and their biological activities were evaluated. Synthesis involved the Gewald reaction to synthesize ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate ring, and S(N)Ar re...

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Detalles Bibliográficos
Autores principales: Islam, Farhana, Doshi, Arpit, Robles, Andrew J., Quadery, Tasdique M., Zhang, Xin, Zhou, Xilin, Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747035/
https://www.ncbi.nlm.nih.gov/pubmed/35011550
http://dx.doi.org/10.3390/molecules27010321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747035/
https://www.ncbi.nlm.nih.gov/pubmed/35011550
http://dx.doi.org/10.3390/molecules27010321

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