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Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents
A series of eleven 4-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines were designed and synthesized and their biological activities were evaluated. Synthesis involved the Gewald reaction to synthesize ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate ring, and S(N)Ar re...
Autores principales: | Islam, Farhana, Doshi, Arpit, Robles, Andrew J., Quadery, Tasdique M., Zhang, Xin, Zhou, Xilin, Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747035/ https://www.ncbi.nlm.nih.gov/pubmed/35011550 http://dx.doi.org/10.3390/molecules27010321 |
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