In silico evaluation of limited sampling strategies for individualized dosing of extended half-life factor IX concentrates in hemophilia B patients

PURPOSE: Hemophilia B is a bleeding disorder, caused by a factor IX (FIX) deficiency. Recently, FIX concentrates with extended half-life (EHL) have become available. Prophylactic dosing of EHL-FIX concentrates can be optimized by assessment of individual pharmacokinetic (PK) parameters. To determine...

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Detalles Bibliográficos
Autores principales: Preijers, T., van Spengler, M. W. F., Meijer, K., Fijnvandraat, K., Fischer, K., Leebeek, F. W. G., Cnossen, M. H., Mathôt, R. A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Pharmacokinetics and Disposition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748341/
https://www.ncbi.nlm.nih.gov/pubmed/34651201
http://dx.doi.org/10.1007/s00228-021-03173-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748341/
https://www.ncbi.nlm.nih.gov/pubmed/34651201
http://dx.doi.org/10.1007/s00228-021-03173-2

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