Single-strand specific nuclease enhances accuracy of error-corrected sequencing and improves rare mutation-detection sensitivity

Error-corrected sequences (ECSs) that utilize double-stranded DNA sequences are useful in detecting mutagen-induced mutations. However, relatively higher frequencies of G:C > T:A (1 × 10(−7) bp) and G:C > C:G (2 × 10(−7) bp) errors decrease the accuracy of detection of rare G:C mutations (appr...

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Detalles Bibliográficos
Autores principales: Otsubo, Yuki, Matsumura, Shoji, Ikeda, Naohiro, Yamane, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748355/
https://www.ncbi.nlm.nih.gov/pubmed/34767040
http://dx.doi.org/10.1007/s00204-021-03185-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748355/
https://www.ncbi.nlm.nih.gov/pubmed/34767040
http://dx.doi.org/10.1007/s00204-021-03185-y

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