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Single-strand specific nuclease enhances accuracy of error-corrected sequencing and improves rare mutation-detection sensitivity
Error-corrected sequences (ECSs) that utilize double-stranded DNA sequences are useful in detecting mutagen-induced mutations. However, relatively higher frequencies of G:C > T:A (1 × 10(−7) bp) and G:C > C:G (2 × 10(−7) bp) errors decrease the accuracy of detection of rare G:C mutations (appr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748355/ https://www.ncbi.nlm.nih.gov/pubmed/34767040 http://dx.doi.org/10.1007/s00204-021-03185-y |