PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer

PHY34 is a synthetic small molecule, inspired by a compound naturally occurring in tropical plants of the Phyllanthus genus. PHY34 was developed to have potent in vitro and in vivo anticancer activity against high grade serous ovarian cancer (HGSOC) cells. Mechanistically, PHY34 induced apoptosis in...

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Detalles Bibliográficos
Autores principales: Salvi, Amrita, Young, Alexandria N., Huntsman, Andrew C., Pergande, Melissa R., Korkmaz, Melissa A., Rathnayake, Rathnayake A., Mize, Brittney K., Kinghorn, A. Douglas, Zhang, Xiaoli, Ratia, Kiira, Schirle, Markus, Thomas, Jason R., Brittain, Scott M., Shelton, Claude, Aldrich, Leslie N., Cologna, Stephanie M., Fuchs, James R., Burdette, Joanna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748433/
https://www.ncbi.nlm.nih.gov/pubmed/35013112
http://dx.doi.org/10.1038/s41419-021-04495-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748433/
https://www.ncbi.nlm.nih.gov/pubmed/35013112
http://dx.doi.org/10.1038/s41419-021-04495-w

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