Transcription Factor Activation Profiles (TFAP) identify compounds promoting differentiation of Acute Myeloid Leukemia cell lines

Repurposing of drugs for new therapeutic use has received considerable attention for its potential to limit time and cost of drug development. Here we present a new strategy to identify chemicals that are likely to promote a desired phenotype. We used data from the Connectivity Map (CMap) to produce...

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Detalles Bibliográficos
Autores principales: Riccio, Federica, Micarelli, Elisa, Secci, Riccardo, Giuliani, Giulio, Vumbaca, Simone, Massacci, Giorgia, Castagnoli, Luisa, Fuoco, Claudia, Cesareni, Gianni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748454/
https://www.ncbi.nlm.nih.gov/pubmed/35013135
http://dx.doi.org/10.1038/s41420-021-00811-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748454/
https://www.ncbi.nlm.nih.gov/pubmed/35013135
http://dx.doi.org/10.1038/s41420-021-00811-7

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