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Redefining the role of Ca(2+)-permeable channels in photoreceptor degeneration using diltiazem

Hereditary degeneration of photoreceptors has been linked to over-activation of Ca(2+)-permeable channels, excessive Ca(2+)-influx, and downstream activation of Ca(2+)-dependent calpain-type proteases. Unfortunately, after more than 20 years of pertinent research, unequivocal evidence proving signif...

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Detalles Bibliográficos
Autores principales: Das, Soumyaparna, Popp, Valerie, Power, Michael, Groeneveld, Kathrin, Yan, Jie, Melle, Christian, Rogerson, Luke, Achury, Marlly, Schwede, Frank, Strasser, Torsten, Euler, Thomas, Paquet-Durand, François, Nache, Vasilica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748460/
https://www.ncbi.nlm.nih.gov/pubmed/35013127
http://dx.doi.org/10.1038/s41419-021-04482-1