Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts

Haploinsufficiency for the erythroid-specific transcription factor KLF1 is associated with hereditary persistence of fetal hemoglobin (HPFH). Increased HbF ameliorates the symptoms of β-hemoglobinopathies and downregulation of KLF1 activity has been proposed as a potential therapeutic strategy. Howe...

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Detalles Bibliográficos
Autores principales: Heshusius, Steven, Grech, Laura, Gillemans, Nynke, Brouwer, Rutger W. W., den Dekker, Xander T., van IJcken, Wilfred F. J., Nota, Benjamin, Felice, Alex E., van Dijk, Thamar B., von Lindern, Marieke, Borg, Joseph, van den Akker, Emile, Philipsen, Sjaak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748495/
https://www.ncbi.nlm.nih.gov/pubmed/35013432
http://dx.doi.org/10.1038/s41598-021-04126-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748495/
https://www.ncbi.nlm.nih.gov/pubmed/35013432
http://dx.doi.org/10.1038/s41598-021-04126-6

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