Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling

Proteome-wide measurements of protein turnover have largely ignored the impact of post-translational modifications (PTMs). To address this gap, we employ stable isotope labeling and mass spectrometry to measure the turnover of >120,000 peptidoforms including >33,000 phosphorylated, acetylated,...

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Detalles Bibliográficos
Autores principales: Zecha, Jana, Gabriel, Wassim, Spallek, Ria, Chang, Yun-Chien, Mergner, Julia, Wilhelm, Mathias, Bassermann, Florian, Kuster, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748498/
https://www.ncbi.nlm.nih.gov/pubmed/35013197
http://dx.doi.org/10.1038/s41467-021-27639-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748498/
https://www.ncbi.nlm.nih.gov/pubmed/35013197
http://dx.doi.org/10.1038/s41467-021-27639-0

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