Association of mutation signature effectuating processes with mutation hotspots in driver genes and non-coding regions

Cancer driving mutations are difficult to identify especially in the non-coding part of the genome. Here, we present sigDriver, an algorithm dedicated to call driver mutations. Using 3813 whole-genome sequenced tumors from International Cancer Genome Consortium, The Cancer Genome Atlas Program, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Wong, John K. L., Aichmüller, Christian, Schulze, Markus, Hlevnjak, Mario, Elgaafary, Shaymaa, Lichter, Peter, Zapatka, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748499/
https://www.ncbi.nlm.nih.gov/pubmed/35013316
http://dx.doi.org/10.1038/s41467-021-27792-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748499/
https://www.ncbi.nlm.nih.gov/pubmed/35013316
http://dx.doi.org/10.1038/s41467-021-27792-6

Ejemplares similares