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Association of mutation signature effectuating processes with mutation hotspots in driver genes and non-coding regions

Cancer driving mutations are difficult to identify especially in the non-coding part of the genome. Here, we present sigDriver, an algorithm dedicated to call driver mutations. Using 3813 whole-genome sequenced tumors from International Cancer Genome Consortium, The Cancer Genome Atlas Program, and...

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Detalles Bibliográficos
Autores principales:	Wong, John K. L., Aichmüller, Christian, Schulze, Markus, Hlevnjak, Mario, Elgaafary, Shaymaa, Lichter, Peter, Zapatka, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748499/ https://www.ncbi.nlm.nih.gov/pubmed/35013316 http://dx.doi.org/10.1038/s41467-021-27792-6

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