RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis

Transforming growth factor-β (TGF-β) acts as a pro-metastatic factor in advanced breast cancer. RNF12, an E3 ubiquitin ligase, stimulates TGF-β signaling by binding to the inhibitory SMAD7 and inducing its proteasomal degradation. How RNF12 activity is regulated and its exact role in cancer is incom...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Yongsheng, Liu, Sijia, Shan, Mengjie, Hagenaars, Sophie C., Mesker, Wilma E., Cohen, Danielle, Wang, Lin, Zheng, Zhi, Devilee, Peter, Tollenaar, Rob A. E. M., Li, Zhangfu, Song, Yongmei, Zhang, Long, Li, Dan, ten Dijke, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748510/
https://www.ncbi.nlm.nih.gov/pubmed/35013159
http://dx.doi.org/10.1038/s41419-021-04493-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748510/
https://www.ncbi.nlm.nih.gov/pubmed/35013159
http://dx.doi.org/10.1038/s41419-021-04493-y

Ejemplares similares