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Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly

Primary microcephaly and megalencephaly are severe brain malformations defined by reduced and increased brain size, respectively. Whether these two pathologies arise from related alterations at the molecular level is unclear. Microcephaly has been largely associated with centrosomal defects, leading...

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Detalles Bibliográficos
Autores principales: Carpentieri, Jacopo A., Di Cicco, Amandine, Lampic, Marusa, Andreau, David, Del Maestro, Laurence, El Marjou, Fatima, Coquand, Laure, Bahi-Buisson, Nadia, Brault, Jean-Baptiste, Baffet, Alexandre D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748540/
https://www.ncbi.nlm.nih.gov/pubmed/35013230
http://dx.doi.org/10.1038/s41467-021-27705-7