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Microfluidic deep mutational scanning of the human executioner caspases reveals differences in structure and regulation
The human caspase family comprises 12 cysteine proteases that are centrally involved in cell death and inflammation responses. The members of this family have conserved sequences and structures, highly similar enzymatic activities and substrate preferences, and overlapping physiological roles. In th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748541/ https://www.ncbi.nlm.nih.gov/pubmed/35013287 http://dx.doi.org/10.1038/s41420-021-00799-0 |