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Microfluidic deep mutational scanning of the human executioner caspases reveals differences in structure and regulation

The human caspase family comprises 12 cysteine proteases that are centrally involved in cell death and inflammation responses. The members of this family have conserved sequences and structures, highly similar enzymatic activities and substrate preferences, and overlapping physiological roles. In th...

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Detalles Bibliográficos
Autores principales:	Roychowdhury, Hridindu, Romero, Philip A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748541/ https://www.ncbi.nlm.nih.gov/pubmed/35013287 http://dx.doi.org/10.1038/s41420-021-00799-0

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