Cargando…

Microfluidic deep mutational scanning of the human executioner caspases reveals differences in structure and regulation

The human caspase family comprises 12 cysteine proteases that are centrally involved in cell death and inflammation responses. The members of this family have conserved sequences and structures, highly similar enzymatic activities and substrate preferences, and overlapping physiological roles. In th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roychowdhury, Hridindu, Romero, Philip A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748541/ https://www.ncbi.nlm.nih.gov/pubmed/35013287 http://dx.doi.org/10.1038/s41420-021-00799-0

Ejemplares similares

Correction to: Microfluidic deep mutational scanning of the human executioner caspases reveals differences in structure and regulation
por: Roychowdhury, Hridindu, et al.
Publicado: (2022)

Exogenous Introduction of Initiator and Executioner Caspases Results in Different Apoptotic Outcomes
por: Anson, Francesca, et al.
Publicado: (2021)

Cell survival following direct executioner-caspase activation
por: Nano, Maddalena, et al.
Publicado: (2023)

Identification and Functional Characterization of Two Executioner Caspases in Crassostrea gigas
por: Qu, Tao, et al.
Publicado: (2014)

Post-transcriptional control of executioner caspases by RNA-binding proteins
por: Subasic, Deni, et al.
Publicado: (2016)

Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine
por: Miles, Mark A, et al.
Publicado: (2017)

Initiator and executioner caspases in salivary gland apoptosis of Rhipicephalus haemaphysaloides
por: Wang, Yanan, et al.
Publicado: (2020)

Regulatory roles of ginseng on inflammatory caspases, executioners of inflammasome activation
por: Yun, Miyong, et al.
Publicado: (2020)

Porcine Gasdermin D Is a Substrate of Caspase-1 and an Executioner of Pyroptosis
por: Song, Yueyang, et al.
Publicado: (2022)

The Cambridge Executioner
Publicado: (1891)

The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases
por: Conde-Rubio, María del Carmen, et al.
Publicado: (2021)

Duck gasdermin E is a substrate of caspase-3/-7 and an executioner of pyroptosis
por: Li, Hanqing, et al.
Publicado: (2023)

MicroRNA-378 Alleviates Cerebral Ischemic Injury by Negatively Regulating Apoptosis Executioner Caspase-3
por: Zhang, Nan, et al.
Publicado: (2016)

Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart
por: Cardona, Maria, et al.
Publicado: (2015)

Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis
por: McKenzie, Brienne A., et al.
Publicado: (2020)

Dronc-independent basal executioner caspase activity sustains Drosophila imaginal tissue growth
por: Shinoda, Natsuki, et al.
Publicado: (2019)

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state
por: Ghazavi, Farzaneh, et al.
Publicado: (2022)

Correction for Nano et al., Cell survival following direct executioner-caspase activation
Publicado: (2023)

Mine Own Executioner
Publicado: (1948)

Venus dye trap catches executioners
por: Dove, Alan W.
Publicado: (2003)

Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach
por: Murphy, Á C, et al.
Publicado: (2013)

Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis
por: Killarney, Shane T., et al.
Publicado: (2023)

Chemotherapy-induced executioner caspase activation increases breast cancer malignancy through epigenetic de-repression of CDH12
por: Wang, Yuxing, et al.
Publicado: (2023)

MLKL: Functions beyond serving as the Executioner of Necroptosis
por: Zhan, Chaoning, et al.
Publicado: (2021)

Cyclophilin D: Guardian or Executioner for Tumor Cells?
por: Zhang, Ling, et al.
Publicado: (2022)

Epigenetics: Judge, jury and executioner of stem cell fate
por: Tollervey, James, et al.
Publicado: (2012)

On the Role of Glycolysis in Early Tumorigenesis—Permissive and Executioner Effects
por: Marcucci, Fabrizio, et al.
Publicado: (2023)

New avenue in the treatment of temporal lobe epilepsy by classical anti-epileptics: A hypothetical establishment of executioner Caspase 3 inactivation by molecular modeling
por: Aanandhi, M. Vijey, et al.
Publicado: (2015)

Iron-dependent cell death as executioner of cancer stem cells
por: Zhao, Bin, et al.
Publicado: (2018)

Deep Mutational Scanning Reveals the Structural Basis for α-Synuclein Activity
por: Newberry, Robert W., et al.
Publicado: (2020)

Hunting down NLRP3 inflammasome: An executioner of radiation-induced injury
por: Cheng, Han, et al.
Publicado: (2022)

Ciphers and Executioners: How 3′-Untranslated Regions Determine the Fate of Messenger RNAs
por: Mayya, Vinay K., et al.
Publicado: (2019)

Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death
por: Li, Yu, et al.
Publicado: (2023)

Cardiovascular Complications Are the Executioners of Inpatient With SARS-CoV-2 Community-Acquired Pneumonia
por: Zeng, Guangting
Publicado: (2023)

Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes
por: Santulli, Gaetano, et al.
Publicado: (2013)

Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins
por: Leander, Megan, et al.
Publicado: (2022)

Inferring protein 3D structure from deep mutation scans
por: Rollins, Nathan J., et al.
Publicado: (2019)

Deep mutational scanning of S. pyogenes Cas9 reveals important functional domains
por: Spencer, Jeffrey M., et al.
Publicado: (2017)

Applications of Deep Mutational Scanning in Virology
por: Burton, Thomas D., et al.
Publicado: (2021)

Neural networks to learn protein sequence–function relationships from deep mutational scanning data
por: Gelman, Sam, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nch05mhluf4e1sc1r2nqcfdcsl