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Missense variants in the TNFA epitopes and their effects on interaction with therapeutic antibodies—in silico analysis
BACKGROUND: Tumor necrosis factor alpha (TNFA) is an important cytokine that influences multiple biological processes. It is one of the key mediators of acute and chronic systemic inflammatory reactions and plays a central role in several autoimmune diseases. A number of approved monoclonal antibodi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748575/ https://www.ncbi.nlm.nih.gov/pubmed/35006391 http://dx.doi.org/10.1186/s43141-021-00288-y |