Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson’s disease

The pathological hallmark of Parkinson’s disease (PD) is the presence of Lewy bodies (LBs) with aggregated α-synuclein being the major component. The abnormal α-synuclein aggregates transfer between cells, recruit endogenous α-synuclein into toxic LBs, and finally trigger neuronal injury. However, t...

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Detalles Bibliográficos
Autores principales: Yan, Mingmin, Xiong, Min, Dai, Lijun, Zhang, Xingyu, Zha, Yunhong, Deng, Xiaorong, Yu, Zhui, Zhang, Zhentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748615/
https://www.ncbi.nlm.nih.gov/pubmed/35013321
http://dx.doi.org/10.1038/s41531-021-00272-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748615/
https://www.ncbi.nlm.nih.gov/pubmed/35013321
http://dx.doi.org/10.1038/s41531-021-00272-w

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