A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues

Proteolysis-targeting chimaeras (PROTACs) as well as molecular glues such as immunomodulatory drugs (IMiDs) and indisulam are drugs that induce interactions between substrate proteins and an E3 ubiquitin ligases for targeted protein degradation. Here, we develop a workflow based on proximity-depende...

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Detalles Bibliográficos
Autores principales: Yamanaka, Satoshi, Horiuchi, Yuto, Matsuoka, Saya, Kido, Kohki, Nishino, Kohei, Maeno, Mayaka, Shibata, Norio, Kosako, Hidetaka, Sawasaki, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748630/
https://www.ncbi.nlm.nih.gov/pubmed/35013300
http://dx.doi.org/10.1038/s41467-021-27818-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748630/
https://www.ncbi.nlm.nih.gov/pubmed/35013300
http://dx.doi.org/10.1038/s41467-021-27818-z

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