Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization

Tumors generate an immune-suppressive environment that prevents effective killing of tumor cells by CD8(+) cytotoxic T cells (CTL). It remains largely unclear upon which cell type and at which stage of the anti-tumor response mediators of suppression act. We have combined an in vivo tumor model with...

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Detalles Bibliográficos
Autores principales: Edmunds, Grace L., Wong, Carissa C. W., Ambler, Rachel, Milodowski, Emily J., Alamir, Hanin, Cross, Stephen J., Galea, Gabriella, Wülfing, Christoph, Morgan, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748690/
https://www.ncbi.nlm.nih.gov/pubmed/35013519
http://dx.doi.org/10.1038/s42003-021-02972-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748690/
https://www.ncbi.nlm.nih.gov/pubmed/35013519
http://dx.doi.org/10.1038/s42003-021-02972-8

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