The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism

Sphingosine 1-phosphate (S1P) is a signaling lipid that has broad roles, working either intracellularly through various protein targets, or extracellularly via a family of five G-protein coupled receptors(.) Agents that selectively and specifically target each of the S1P receptors have been sought a...

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Detalles Bibliográficos
Autores principales: Pitman, Melissa R., Lewis, Alexander C., Davies, Lorena T., Moretti, Paul A. B., Anderson, Dovile, Creek, Darren J., Powell, Jason A., Pitson, Stuart M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748775/
https://www.ncbi.nlm.nih.gov/pubmed/35013382
http://dx.doi.org/10.1038/s41598-021-04009-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748775/
https://www.ncbi.nlm.nih.gov/pubmed/35013382
http://dx.doi.org/10.1038/s41598-021-04009-w

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