EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Efforts to therapeutically target EZH2 have generally focused on inhibition of its methyltransferase activity, although it remains less clear whether this is the central mechanism whereby EZH2 promotes cancer. In the current study, we show that EZH2 directly interacts with both MYC family oncoprotei...

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Detalles Bibliográficos
Autores principales: Wang, Liyuan, Chen, Chan, Song, Zemin, Wang, Honghong, Ye, Minghui, Wang, Donghai, Kang, Wenqian, Liu, Hudan, Qing, Guoliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748958/
https://www.ncbi.nlm.nih.gov/pubmed/35013218
http://dx.doi.org/10.1038/s41467-021-27609-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748958/
https://www.ncbi.nlm.nih.gov/pubmed/35013218
http://dx.doi.org/10.1038/s41467-021-27609-6

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