NLK is required for Ras/ERK/SRF/ELK signaling to tune skeletal muscle development by phosphorylating SRF and antagonizing the SRF/MKL pathway

Serum response factor (SRF) regulates differentiation and proliferation by binding to RhoA-actin-activated MKL or Ras-MAPK-activated ELK transcriptional coactivators, but the molecular mechanisms responsible for SRF regulation remain unclear. Here, we show that Nemo-like kinase (NLK) is required for...

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Detalles Bibliográficos
Autores principales: Li, Shang-Ze, Zhang, Ze-Yan, Chen, Jie, Dong, Ming-You, Du, Xue-Hua, Gao, Jie, Shu, Qi-Peng, Li, Chao, Liang, Xin-Yi, Ding, Zhi-Hao, Du, Run-Lei, Wang, Junli, Zhang, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748963/
https://www.ncbi.nlm.nih.gov/pubmed/35013153
http://dx.doi.org/10.1038/s41420-021-00774-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748963/
https://www.ncbi.nlm.nih.gov/pubmed/35013153
http://dx.doi.org/10.1038/s41420-021-00774-9

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