Accumulation of APP-CTF induces mitophagy dysfunction in the iNSCs model of Alzheimer’s disease

Mitochondrial dysfunction is associated with familial Alzheimer’s disease (fAD), and the accumulation of damaged mitochondria has been reported as an initial symptom that further contributes to disease progression. In the amyloidogenic pathway, the amyloid precursor protein (APP) is cleaved by β-sec...

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Detalles Bibliográficos
Autores principales: Lee, Seung-Eun, Kwon, Daekee, Shin, Nari, Kong, Dasom, Kim, Nam Gyo, Kim, Hee-Yeong, Kim, Min-Ji, Choi, Soon Won, Kang, Kyung-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748980/
https://www.ncbi.nlm.nih.gov/pubmed/35013145
http://dx.doi.org/10.1038/s41420-021-00796-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748980/
https://www.ncbi.nlm.nih.gov/pubmed/35013145
http://dx.doi.org/10.1038/s41420-021-00796-3

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