Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome

Dravet syndrome is a severe epileptic encephalopathy caused primarily by haploinsufficiency of the SCN1A gene. Repetitive seizures can lead to endurable and untreatable neurological deficits. Whether this severe pathology is reversible after symptom onset remains unknown. To address this question, w...

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Detalles Bibliográficos
Autores principales: Valassina, Nicholas, Brusco, Simone, Salamone, Alessia, Serra, Linda, Luoni, Mirko, Giannelli, Serena, Bido, Simone, Massimino, Luca, Ungaro, Federica, Mazzara, Pietro Giuseppe, D’Adamo, Patrizia, Lignani, Gabriele, Broccoli, Vania, Colasante, Gaia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748984/
https://www.ncbi.nlm.nih.gov/pubmed/35013317
http://dx.doi.org/10.1038/s41467-021-27837-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748984/
https://www.ncbi.nlm.nih.gov/pubmed/35013317
http://dx.doi.org/10.1038/s41467-021-27837-w

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