Cargando…
Statins mediate anti- and pro-tumourigenic functions by remodelling the tumour microenvironment
Anti-cancer properties of statins are controversial and possibly context dependent. Recent pathology/epidemiology studies of human lung adenocarcinoma showed reduced pro-tumourigenic macrophages associated with a shift to lower-grade tumours amongst statin users but, paradoxically, worse survival co...
Autores principales: | Kamata, Tamihiro, Al Dujaily, Esraa, Alhamad, Salwa, So, Tsz Y., Margaritaki, Olga, Giblett, Susan, Pringle, J. Howard, Le Quesne, John, Pritchard, Catrin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749029/ https://www.ncbi.nlm.nih.gov/pubmed/34779486 http://dx.doi.org/10.1242/dmm.049148 |
Ejemplares similares
-
Reduced Protumorigenic Tumor-Associated Macrophages With Statin Use in Premalignant Human Lung Adenocarcinoma
por: Al Dujaily, Esraa, et al.
Publicado: (2019) -
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development
por: Kamata, Tamihiro, et al.
Publicado: (2020) -
The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours
por: Kamata, Tamihiro, et al.
Publicado: (2015) -
Matter of TIME: the tumor-immune microenvironment of mesothelioma and implications for checkpoint blockade efficacy
por: Harber, James, et al.
Publicado: (2021) -
Elevated level of inhibin-α subunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer
por: Balanathan, P, et al.
Publicado: (2009)