Cargando…

Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation

Abnormal activation of SETBP1 due to overexpression or missense mutations occurs frequently in various myeloid neoplasms and associates with poor prognosis. Direct activation of Hoxa9/Hoxa10/Myb transcription by SETBP1 and its missense mutants is essential for their transforming capability; however,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Nhu, Gudmundsson, Kristbjorn O., Soltis, Anthony R., Oakley, Kevin, Roy, Kartik R., Han, Yufen, Gurnari, Carmelo, Maciejewski, Jaroslaw P., Crouch, Gary, Ernst, Patricia, Dalgard, Clifton L., Du, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749219/ https://www.ncbi.nlm.nih.gov/pubmed/35036869 http://dx.doi.org/10.1016/j.isci.2021.103679

Ejemplares similares

Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development
por: Vishwakarma, Bandana A., et al.
Publicado: (2015)

Myb expression is critical for myeloid leukemia development induced by Setbp1 activation
por: Nguyen, Nhu, et al.
Publicado: (2016)

Somatic SETBP1 mutations in myeloid malignancies
por: Makishima, Hideki, et al.
Publicado: (2013)

Identification of a novel de novo mutation of SETBP1 and new findings of SETBP1 in tumorgenesis
por: Wang, Hongdan, et al.
Publicado: (2023)

SETBP1 dysregulation in congenital disorders and myeloid neoplasms
por: Coccaro, Nicoletta, et al.
Publicado: (2017)

Putative Roles of SETBP1 Dosage on the SET Oncogene to Affect Brain Development
por: Antonyan, Lilit, et al.
Publicado: (2022)

From Bench to Bedside and Beyond: Therapeutic Scenario in Acute Myeloid Leukemia
por: Gurnari, Carmelo, et al.
Publicado: (2020)

The Role of SETBP1 in Gastric Cancer: Friend or Foe
por: Fang, Fujin, et al.
Publicado: (2022)

Large Granular Lymphocytic Leukemia: From Immunopathogenesis to Treatment of Refractory Disease
por: Zawit, Misam, et al.
Publicado: (2021)

An enhancer RNA recruits MLL1 to regulate transcription of Myb
por: Kim, Juhyun, et al.
Publicado: (2023)

SETBP1 Mutations Drive Leukemic Transformation in ASXL1-Mutated MDS
por: Inoue, Daichi, et al.
Publicado: (2014)

Novel SETBP1 mutation in a chinese family with intellectual disability
por: Wang, Le, et al.
Publicado: (2023)

SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia
por: Albano, Francesco, et al.
Publicado: (2012)

CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia
por: Cui, Yajuan, et al.
Publicado: (2014)

SETBP1 mutations as a biomarker for myelodysplasia /myeloproliferative neoplasm overlap syndrome
por: Linder, Katherine, et al.
Publicado: (2017)

SETBP1 mutation determines sensitivity to immune checkpoint inhibitors in melanoma and NSCLC
por: An, Fengxiao, et al.
Publicado: (2023)

SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
por: Piazza, Rocco, et al.
Publicado: (2018)

Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies
por: Acuna-Hidalgo, Rocio, et al.
Publicado: (2017)

The landscape of SETBP1 gene expression and transcription factor activity across human tissues
por: Whitlock, Jordan H., et al.
Publicado: (2023)

A novel mutation of SETBP1 in atypical chronic myeloid leukemia transformed from acute myelomonocytic leukemia
por: Hu, WangQiang, et al.
Publicado: (2015)

Evaluation of a father and son with atypical chronic myeloid leukemia with SETBP1 mutations and a review of the literature
por: Wang, L., et al.
Publicado: (2015)

P726: TET2 ALLELIC BURDEN IMPRINTS A CONTEXT-DEPENDENT PROGNOSTIC SIGNIFICANCE OF ASXL1 MUTATION IN CHRONIC MYELOMONOCYTIC LEUKAEMIA
por: Wang, Yu-Hung, et al.
Publicado: (2023)

Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis
por: Grigsby, Sierrah M., et al.
Publicado: (2021)

SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML
por: Laborde, R R, et al.
Publicado: (2013)

A non‐cytotoxic regimen of decitabine to treat refractory T‐cell large granular lymphocytic leukemia
por: Zawit, Misam, et al.
Publicado: (2021)

Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia
por: Teague, Destini, et al.
Publicado: (2022)

Detection of a novel SETBP1 variant in a Chinese neonate with Schinzel–Giedion syndrome
por: Yang, Hansong, et al.
Publicado: (2022)

Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in SETBP1, SRSF2, ASXL1 and NRAS
por: Kanagal-Shamanna, Rashmi, et al.
Publicado: (2016)

UBA1 Screening in Sweet Syndrome With Hematological Neoplasms Reveals a Novel Association Between VEXAS and Chronic Myelomonocytic Leukemia
por: Gurnari, Carmelo, et al.
Publicado: (2022)

New approaches to idiopathic neutropenia in the era of clonal hematopoiesis
por: Ogbue, Olisaemeka D., et al.
Publicado: (2023)

FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis
por: Mitchell, Allison V., et al.
Publicado: (2022)

Identification of SETBP1 Mutations by Gene Panel Sequencing in Individuals With Intellectual Disability or With “Developmental and Epileptic Encephalopathy”
por: Leonardi, Emanuela, et al.
Publicado: (2020)

Impact of TET2, SRSF2, ASXL1 and SETBP1 mutations on survival of patients with chronic myelomonocytic leukemia
por: Cui, Yajuan, et al.
Publicado: (2015)

ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation
por: Saika, Makoto, et al.
Publicado: (2018)

MutEnricher: a flexible toolset for somatic mutation enrichment analysis of tumor whole genomes
por: Soltis, Anthony R., et al.
Publicado: (2020)

MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program
por: Xu, Jing, et al.
Publicado: (2016)

Developmentally-induced Mll1 loss reveals defects in postnatal haematopoiesis
por: Gan, Tao, et al.
Publicado: (2010)

Prenatal diagnosis and molecular cytogenetic characterization of an inherited microdeletion of 18q12.3 encompassing SETBP1
por: Zhou, Yaqing, et al.
Publicado: (2022)

Impaired neurogenesis and neural progenitor fate choice in a human stem cell model of SETBP1 disorder
por: Cardo, Lucia F., et al.
Publicado: (2023)

Essential Functions of MLL1 and MLL2 in Retinal Development and Cone Cell Maintenance
por: Sun, Chi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2q7idq5fdq1d02dgu939sghdh2