Ionizing Radiation Upregulates Glutamine Metabolism and Induces Cell Death via Accumulation of Reactive Oxygen Species

Glutamine metabolism provides energy to tumor cells and also produces reactive oxygen species (ROS). Excessive accumulation of ROS can damage mitochondria and eventually lead to cell death. xCT (SLC7A11) is responsible for the synthesis of glutathione in order to neutralize ROS. In addition, mitopha...

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Detalles Bibliográficos
Autores principales: Yang, Pengfei, Luo, Xiangxia, Li, Jin, Zhang, Tianyi, Gao, Xiaoling, Hua, Junrui, Li, Yonghong, Ding, Nan, He, Jinpeng, Zhang, Yanan, Wei, Wenjun, Wang, Jufang, Zhou, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749225/
https://www.ncbi.nlm.nih.gov/pubmed/35028001
http://dx.doi.org/10.1155/2021/5826932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749225/
https://www.ncbi.nlm.nih.gov/pubmed/35028001
http://dx.doi.org/10.1155/2021/5826932

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