Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3β,12β,25-triol derivatives as α-glucosidase and PTP1B inhibitors

The dammarane triterpenoid (20S,24R)-epoxy-dammarane-3β,12β,25-triol obtained from Cyclocarya paliurus in our previous study showed inhibitory activity on α-glucosidase in vitro with an inhibitory ratio of 32.2% at the concentration of 200 μM. In order to reveal the structure-activity relationships...

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Detalles Bibliográficos
Autores principales: Yang, Xiao-Tong, Li, Tian-Ze, Geng, Chang-An, Liu, Pei, Chen, Ji-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749348/
https://www.ncbi.nlm.nih.gov/pubmed/35035203
http://dx.doi.org/10.1007/s00044-021-02836-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749348/
https://www.ncbi.nlm.nih.gov/pubmed/35035203
http://dx.doi.org/10.1007/s00044-021-02836-0

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