Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor

Loss of the furin cleavage motif in the SARS-CoV-2 spike protein reduces the virulence and transmission of SARS-CoV-2, suggesting that furin is an attractive antiviral drug target. However, lack of understanding of the regulation of furin activity has largely limited the development of furin-based t...

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Detalles Bibliográficos
Autores principales: Wang, Jinliang, Luo, Jie, Wen, Zhiyuan, Wang, Xinxin, Shuai, Lei, Zhong, Gongxun, Wang, Chong, Sun, Ziruo, Chen, Weiye, Ge, Jinying, Liu, Renqiang, Wang, Xijun, Bu, Zhigao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749436/
https://www.ncbi.nlm.nih.gov/pubmed/35012335
http://dx.doi.org/10.1128/mbio.02443-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749436/
https://www.ncbi.nlm.nih.gov/pubmed/35012335
http://dx.doi.org/10.1128/mbio.02443-21

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