The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2

Transcription factor Nrf2 and its negative regulator Keap1 orchestrate a cytoprotective response against oxidative, metabolic, and inflammatory stress. Keap1 is a drug target, with several small molecules in drug development. Here, we show that the isoquinoline PRL-295 increased Keap1 thermostabilit...

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Detalles Bibliográficos
Autores principales: Dayalan Naidu, Sharadha, Suzuki, Takafumi, Dikovskaya, Dina, Knatko, Elena V., Higgins, Maureen, Sato, Miu, Novak, Miroslav, Villegas, José A., Moore, Terry W., Yamamoto, Masayuki, Dinkova-Kostova, Albena T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749459/
https://www.ncbi.nlm.nih.gov/pubmed/35036882
http://dx.doi.org/10.1016/j.isci.2021.103703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749459/
https://www.ncbi.nlm.nih.gov/pubmed/35036882
http://dx.doi.org/10.1016/j.isci.2021.103703

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