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The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2
Transcription factor Nrf2 and its negative regulator Keap1 orchestrate a cytoprotective response against oxidative, metabolic, and inflammatory stress. Keap1 is a drug target, with several small molecules in drug development. Here, we show that the isoquinoline PRL-295 increased Keap1 thermostabilit...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749459/ https://www.ncbi.nlm.nih.gov/pubmed/35036882 http://dx.doi.org/10.1016/j.isci.2021.103703 |