SARS-CoV-2 Spike protein is not pro-inflammatory in human primary macrophages: endotoxin contamination and lack of protein glycosylation as possible confounders

INTRODUCTION: The inflammatory potential of SARS-CoV-2 Spike S1 (Spike) has never been tested in human primary macrophages (MΦ). Different recombinant Spikes might display different effects in vitro, according to protein length and glycosylation, and endotoxin (lipopolysaccharide, LPS) contamination...

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Detalles Bibliográficos
Autores principales: Cinquegrani, Gloria, Spigoni, Valentina, Iannozzi, Nicolas Thomas, Parello, Vanessa, Bonadonna, Riccardo C., Dei Cas, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749924/
https://www.ncbi.nlm.nih.gov/pubmed/35015170
http://dx.doi.org/10.1007/s10565-021-09693-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749924/
https://www.ncbi.nlm.nih.gov/pubmed/35015170
http://dx.doi.org/10.1007/s10565-021-09693-y

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