High Throughput Small Molecule Screen for Reactivation of FMR1 in Fragile X Syndrome Human Neural Cells

Fragile X syndrome (FXS) is the most common inherited cause of autism and intellectual disability. The majority of FXS cases are caused by transcriptional repression of the FMR1 gene due to epigenetic changes that are not recapitulated in current animal disease models. FXS patient induced pluripoten...

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Detalles Bibliográficos
Autores principales: Hunt, Jack F. V., Li, Meng, Risgaard, Ryan, Ananiev, Gene E., Wildman, Scott, Zhang, Fan, Bugni, Tim S., Zhao, Xinyu, Bhattacharyya, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750025/
https://www.ncbi.nlm.nih.gov/pubmed/35011630
http://dx.doi.org/10.3390/cells11010069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750025/
https://www.ncbi.nlm.nih.gov/pubmed/35011630
http://dx.doi.org/10.3390/cells11010069

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