Cargando…
HPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes
SIMPLE SUMMARY: Cervical cancer is one of the most common cancers in women. More than 95% of the cervical cancers are caused by the human papilloma viruses. Earlier we had identified a protein target, USP46 that can be inhibited to block the cancer growth. We found that the viral E6 and human USP46...
Autores principales: | Kiran, Shashi, Wilson, Briana, Saha, Shekhar, Graff, Julia Ann, Dutta, Anindya |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750077/ https://www.ncbi.nlm.nih.gov/pubmed/35008200 http://dx.doi.org/10.3390/cancers14010030 |
Ejemplares similares
-
Structural insights into the activation of USP46 by WDR48 and WDR20
por: Zhu, Hanwen, et al.
Publicado: (2019) -
Transcriptome analysis of cervical cancer exosomes and detection of HPVE6*I transcripts in exosomal RNA
por: Bhat, Anjali, et al.
Publicado: (2022) -
Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28
por: Toth, Rachel K., et al.
Publicado: (2022) -
Cdt1 stabilizes an open MCM ring for helicase loading
por: Frigola, Jordi, et al.
Publicado: (2017) -
Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract
por: Henkle, Talia R., et al.
Publicado: (2021)