Potassium Effects on NCC Are Attenuated during Inhibition of Cullin E3–Ubiquitin Ligases

The thiazide-sensitive sodium chloride cotransporter (NCC) plays a vital role in maintaining sodium (Na(+)) and potassium (K(+)) homeostasis. NCC activity is modulated by with-no-lysine kinases 1 and 4 (WNK1 and WNK4), the abundance of which is controlled by the RING-type E3 ligase Cullin 3 (Cul3) a...

Descripción completa

Detalles Bibliográficos
Autores principales: Murali, Sathish K., Little, Robert, Poulsen, Søren B., Ferdaus, Mohammed Z., Ellison, David H., McCormick, James A., Fenton, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750104/
https://www.ncbi.nlm.nih.gov/pubmed/35011657
http://dx.doi.org/10.3390/cells11010095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750104/
https://www.ncbi.nlm.nih.gov/pubmed/35011657
http://dx.doi.org/10.3390/cells11010095

Ejemplares similares