Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A

Although some therapeutic progress has been achieved in developing small molecules that correct F508del-CFTR defects, the mechanism of action (MoA) of these compounds remain poorly elucidated. Here, we investigated the effects and MoA of MCG1516A, a newly developed F508del-CFTR corrector. MCG1516A e...

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Detalles Bibliográficos
Autores principales: Lopes-Pacheco, Miquéias, Bacalhau, Mafalda, Ramalho, Sofia S., Silva, Iris A. L., Ferreira, Filipa C., Carlile, Graeme W., Thomas, David Y., Farinha, Carlos M., Hanrahan, John W., Amaral, Margarida D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750248/
https://www.ncbi.nlm.nih.gov/pubmed/35011698
http://dx.doi.org/10.3390/cells11010136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750248/
https://www.ncbi.nlm.nih.gov/pubmed/35011698
http://dx.doi.org/10.3390/cells11010136

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