Cargando…

Whole-Exome Sequencing of HPV Positive Tonsillar and Base of Tongue Squamous Cell Carcinomas Reveals a Global Mutational Pattern along with Relapse-Specific Somatic Variants

SIMPLE SUMMARY: To better prevent/combat recurrence and identify predictive/targetable markers upon diagnosis, we performed whole-exome sequencing (WES) of primary tumours and relapses of human papillomavirus positive (HPV(+)) tonsillar and base of tongue cancer (TSCC/BOTSCC) on patients treated wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ährlund-Richter, Andreas, Holzhauser, Stefan, Dalianis, Tina, Näsman, Anders, Mints, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750256/ https://www.ncbi.nlm.nih.gov/pubmed/35008243 http://dx.doi.org/10.3390/cancers14010077

Ejemplares similares

Prognostic Markers and Driver Genes and Options for Targeted Therapy in Human-Papillomavirus-Positive Tonsillar and Base-of-Tongue Squamous Cell Carcinoma
por: Näsman, Anders, et al.
Publicado: (2021)

Targeted sequencing of tonsillar and base of tongue cancer and human papillomavirus positive unknown primary of the head and neck reveals prognostic effects of mutated FGFR3
por: Bersani, Cinzia, et al.
Publicado: (2017)

Differences in gene expression between high‐grade dysplasia and invasive HPV(+) and HPV(−) tonsillar and base of tongue cancer
por: Haeggblom, Linnea, et al.
Publicado: (2019)

Post-Treatment Neck Dissection of Tonsillar and Base of Tongue Squamous Cell Carcinoma in the Era of PET-CT, HPV, and p16
por: Landin, David, et al.
Publicado: (2022)

Correlation of LMP10 Expression and Clinical Outcome in Human Papillomavirus (HPV) Positive and HPV-Negative Tonsillar and Base of Tongue Cancer
por: Tertipis, Nikolaos, et al.
Publicado: (2014)

Human papilloma virus (HPV) prevalence upon HPV vaccination in Swedish youth: a review based on our findings 2008–2018, and perspectives on cancer prevention
por: Du, Juan, et al.
Publicado: (2020)

Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome
por: Ramqvist, Torbjörn, et al.
Publicado: (2018)

Targeted Therapy With PI3K and FGFR Inhibitors on Human Papillomavirus Positive and Negative Tonsillar and Base of Tongue Cancer Lines With and Without Corresponding Mutations
por: Holzhauser, Stefan, et al.
Publicado: (2021)

Human Papillomavirus and Tonsillar and Base of Tongue Cancer
por: Ramqvist, Torbjörn, et al.
Publicado: (2015)

Human Papillomavirus (HPV) 16 E6 Variants in Tonsillar Cancer in Comparison to Those in Cervical Cancer in Stockholm, Sweden
por: Du, Juan, et al.
Publicado: (2012)

Reduced Expression of the Antigen Processing Machinery Components TAP2, LMP2, and LMP7 in Tonsillar and Base of Tongue Cancer and Implications for Clinical Outcome()
por: Tertipis, Nikolaos, et al.
Publicado: (2015)

Analysis of Human Papillomavirus (HPV) and Polyomaviruses (HPyVs) in Adenoid Cystic Carcinoma (AdCC) of the Head and Neck Region Reveals Three HPV-Positive Cases with Adenoid Cystic-like Features
por: Zupancic, Mark, et al.
Publicado: (2022)

Targeted Therapy with PI3K, PARP, and WEE1 Inhibitors and Radiotherapy in HPV Positive and Negative Tonsillar Squamous Cell Carcinoma Cell Lines Reveals Synergy while Effects with APR-246 Are Limited
por: Byskata, Karin, et al.
Publicado: (2022)

Tumor Infiltrating CD8(+) and Foxp3(+) Lymphocytes Correlate to Clinical Outcome and Human Papillomavirus (HPV) Status in Tonsillar Cancer
por: Näsman, Anders, et al.
Publicado: (2012)

High Levels of FGF11 Correlate with Poor Survival in Patients with Human Papillomavirus (HPV)-Positive Oropharyngeal Squamous Cell Carcinoma
por: de Flon, Caroline Haglund, et al.
Publicado: (2023)

Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma
por: Zupancic, Mark, et al.
Publicado: (2021)

Special Issue “HPV in the Head and Neck Region”
por: Dalianis, Tina, et al.
Publicado: (2021)

Targeted Therapy of HPV Positive and Negative Tonsillar Squamous Cell Carcinoma Cell Lines Reveals Synergy between CDK4/6, PI3K and Sometimes FGFR Inhibitors, but Rarely between PARP and WEE1 Inhibitors
por: Kostopoulou, Ourania N., et al.
Publicado: (2022)

Special Issue “HPV in the Head and Neck Region 2.0”
por: Dalianis, Tina, et al.
Publicado: (2023)

Time to change perspectives on HPV in oropharyngeal cancer. A systematic review of HPV prevalence per oropharyngeal sub-site the last 3 years
por: Haeggblom, Linnea, et al.
Publicado: (2017)

Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma
por: Haeggblom, Linnea, et al.
Publicado: (2018)

Prevalence of Oral Human Papillomavirus Infection among Youth, Sweden
por: Du, Juan, et al.
Publicado: (2012)

Tumour inflammation signature and expression of S100A12 and HLA class I improve survival in HPV-negative hypopharyngeal cancer
por: Mints, Michael, et al.
Publicado: (2021)

Prevalence of human papillomavirus and survival in oropharyngeal cancer other than tonsil or base of tongue cancer
por: Marklund, Linda, et al.
Publicado: (2012)

Long-Term Survival and Recurrence in Oropharyngeal Squamous Cell Carcinoma in Relation to Subsites, HPV, and p16-Status
por: Wendt, Malin, et al.
Publicado: (2021)

Prevalence of Human Papillomavirus (HPV) in Oesophageal Squamous Cell Carcinoma in Relation to Anatomical Site of the Tumour
por: Löfdahl, Hedvig E., et al.
Publicado: (2012)

Absent/weak CD44 intensity and positive human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma indicates a very high survival
por: Näsman, Anders, et al.
Publicado: (2013)

HLA Class I and II Expression in Oropharyngeal Squamous Cell Carcinoma in Relation to Tumor HPV Status and Clinical Outcome
por: Näsman, Anders, et al.
Publicado: (2013)

Epidemiology and survival of HPV-related tonsillar carcinoma
por: Psychogios, Georgios, et al.
Publicado: (2014)

Changes in Cervical Human Papillomavirus (HPV) Prevalence at a Youth Clinic in Stockholm, Sweden, a Decade After the Introduction of the HPV Vaccine
por: Ährlund-Richter, Andreas, et al.
Publicado: (2019)

Adenoid Cystic Carcinoma (AdCC): A Clinical Survey of a Large Patient Cohort
por: Zupancic, Mark, et al.
Publicado: (2023)

miRNA-expression in tonsillar squamous cell carcinomas in relation to HPV infection and expression of the antileukoproteinase SLPI
por: Quabius, Elgar Susanne, et al.
Publicado: (2017)

Single-cell analysis of myeloid cells in HPV(+) tonsillar cancer
por: Jimenez, David Gomez, et al.
Publicado: (2023)

Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status
por: Gama-Cuellar, Ana Guadalupe, et al.
Publicado: (2022)

HPV positive tonsillar cancer in two laser surgeons: case reports
por: Rioux, Margo, et al.
Publicado: (2013)

A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing
por: Nichols, Anthony C., et al.
Publicado: (2012)

Fanconi anaemia presenting as tonsillar squamous cell carcinoma
por: Sarma, Y. S., et al.
Publicado: (2018)

Distinct microbial communities colonize tonsillar squamous cell carcinoma
por: De Martin, Angelina, et al.
Publicado: (2021)

Combination of PARP and WEE1 inhibitors in vitro: Potential for use in the treatment of SHH medulloblastoma
por: Lukoseviciute, Monika, et al.
Publicado: (2023)

Tonsillar Microbiota: a Cross-Sectional Study of Patients with Chronic Tonsillitis or Tonsillar Hypertrophy
por: Wu, Shengru, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vcalid0ev15lh4305pkojn1ut9