Golgi Alpha1,2-Mannosidase IA Promotes Efficient Endoplasmic Reticulum-Associated Degradation of NKCC2

Mutations in the apically located kidney Na-K-2Cl cotransporter NKCC2 cause type I Bartter syndrome, a life-threatening kidney disorder. We previously showed that transport from the ER represents the limiting phase in NKCC2 journey to the cell surface. Yet very little is known about the ER quality c...

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Detalles Bibliográficos
Autores principales: Demaretz, Sylvie, Seaayfan, Elie, Bakhos-Douaihy, Dalal, Frachon, Nadia, Kömhoff, Martin, Laghmani, Kamel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750359/
https://www.ncbi.nlm.nih.gov/pubmed/35011665
http://dx.doi.org/10.3390/cells11010101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750359/
https://www.ncbi.nlm.nih.gov/pubmed/35011665
http://dx.doi.org/10.3390/cells11010101

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