TNFα Mediates Inflammation-Induced Effects on PPARG Splicing in Adipose Tissue and Mesenchymal Precursor Cells

Low-grade chronic inflammation and reduced differentiation capacity are hallmarks of hypertrophic adipose tissue (AT) and key contributors of insulin resistance. We identified PPARGΔ5 as a dominant-negative splicing isoform overexpressed in the AT of obese/diabetic patients able to impair adipocyte...

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Detalles Bibliográficos
Autores principales: Cataldi, Simona, Aprile, Marianna, Melillo, Daniela, Mucel, Inès, Giorgetti-Peraldi, Sophie, Cormont, Mireille, Italiani, Paola, Blüher, Matthias, Tanti, Jean-François, Ciccodicola, Alfredo, Costa, Valerio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750445/
https://www.ncbi.nlm.nih.gov/pubmed/35011604
http://dx.doi.org/10.3390/cells11010042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750445/
https://www.ncbi.nlm.nih.gov/pubmed/35011604
http://dx.doi.org/10.3390/cells11010042

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