Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppression

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Conserved SARS-CoV-2 RNA regions of critical biological functions define excellent targets for anti-viral therapeutics against Covid-19 variants. One such region is the frameshifting element (FSE), responsible for correct translation of viral polyproteins. Here, we analyze molecular-dynamics motions...

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Detalles Bibliográficos
Autores principales: Yan, Shuting, Zhu, Qiyao, Jain, Swati, Schlick, Tamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750709/
https://www.ncbi.nlm.nih.gov/pubmed/35018371
http://dx.doi.org/10.21203/rs.3.rs-1160075/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750709/
https://www.ncbi.nlm.nih.gov/pubmed/35018371
http://dx.doi.org/10.21203/rs.3.rs-1160075/v1

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