Integrin/TGF-β1 inhibitor GLPG-0187 blocks SARS-CoV-2 Delta and Omicron pseudovirus infection of airway epithelial cells which could attenuate disease severity

As COVID-19 continues to pose major risk for vulnerable populations including the elderly, immunocompromised, patients with cancer, and those with contraindications to vaccination, novel treatment strategies are urgently needed. SARS-CoV-2 infects target cells via RGD-binding integrins either indepe...

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Detalles Bibliográficos
Autores principales: Huntington, Kelsey E., Carlsen, Lindsey, So, Eui-Young, Piesche, Matthias, Liang, Olin, El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750711/
https://www.ncbi.nlm.nih.gov/pubmed/35018385
http://dx.doi.org/10.1101/2022.01.02.22268641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750711/
https://www.ncbi.nlm.nih.gov/pubmed/35018385
http://dx.doi.org/10.1101/2022.01.02.22268641

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