Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues

The transposon theory of aging hypothesizes the activation of transposable elements (TEs) in somatic tissues with age, leading to a shortening of the lifespan. It is thought that TE activation in aging produces an increase in DNA double-strand breaks, contributing to genome instability and promoting...

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Autores principales: Giordani, Giorgia, Cavaliere, Valeria, Gargiulo, Giuseppe, Lattanzi, Giovanna, Andrenacci, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750722/
https://www.ncbi.nlm.nih.gov/pubmed/35011640
http://dx.doi.org/10.3390/cells11010079
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author Giordani, Giorgia
Cavaliere, Valeria
Gargiulo, Giuseppe
Lattanzi, Giovanna
Andrenacci, Davide
author_facet Giordani, Giorgia
Cavaliere, Valeria
Gargiulo, Giuseppe
Lattanzi, Giovanna
Andrenacci, Davide
author_sort Giordani, Giorgia
collection PubMed
description The transposon theory of aging hypothesizes the activation of transposable elements (TEs) in somatic tissues with age, leading to a shortening of the lifespan. It is thought that TE activation in aging produces an increase in DNA double-strand breaks, contributing to genome instability and promoting the activation of inflammatory responses. To investigate how TE regulation changes in somatic tissues during aging, we analyzed the expression of some TEs, as well as a source of small RNAs that specifically silence the analyzed TEs; the Drosophila cluster named flamenco. We found significant variations in the expression levels of all the analyzed TEs during aging, with a trend toward reduction in middle-aged adults and reactivation in older individuals that suggests dynamic regulation during the lifespan.
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spelling pubmed-87507222022-01-12 Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues Giordani, Giorgia Cavaliere, Valeria Gargiulo, Giuseppe Lattanzi, Giovanna Andrenacci, Davide Cells Communication The transposon theory of aging hypothesizes the activation of transposable elements (TEs) in somatic tissues with age, leading to a shortening of the lifespan. It is thought that TE activation in aging produces an increase in DNA double-strand breaks, contributing to genome instability and promoting the activation of inflammatory responses. To investigate how TE regulation changes in somatic tissues during aging, we analyzed the expression of some TEs, as well as a source of small RNAs that specifically silence the analyzed TEs; the Drosophila cluster named flamenco. We found significant variations in the expression levels of all the analyzed TEs during aging, with a trend toward reduction in middle-aged adults and reactivation in older individuals that suggests dynamic regulation during the lifespan. MDPI 2021-12-28 /pmc/articles/PMC8750722/ /pubmed/35011640 http://dx.doi.org/10.3390/cells11010079 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Giordani, Giorgia
Cavaliere, Valeria
Gargiulo, Giuseppe
Lattanzi, Giovanna
Andrenacci, Davide
Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues
title Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues
title_full Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues
title_fullStr Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues
title_full_unstemmed Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues
title_short Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues
title_sort retrotransposons down- and up-regulation in aging somatic tissues
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750722/
https://www.ncbi.nlm.nih.gov/pubmed/35011640
http://dx.doi.org/10.3390/cells11010079
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AT lattanzigiovanna retrotransposonsdownandupregulationinagingsomatictissues
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