Glutamine-Derived Aspartate Biosynthesis in Cancer Cells: Role of Mitochondrial Transporters and New Therapeutic Perspectives

SIMPLE SUMMARY: In recent years, aspartate has been increasingly acknowledged as a critical player in the metabolism of cancer cells which use this metabolite for nucleotide and protein synthesis and for redox homeostasis. Most intracellular aspartate derives from the mitochondrial catabolism of glu...

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Detalles Bibliográficos
Autores principales: Gorgoglione, Ruggiero, Impedovo, Valeria, Riley, Christopher L., Fratantonio, Deborah, Tiziani, Stefano, Palmieri, Luigi, Dolce, Vincenza, Fiermonte, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750728/
https://www.ncbi.nlm.nih.gov/pubmed/35008407
http://dx.doi.org/10.3390/cancers14010245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750728/
https://www.ncbi.nlm.nih.gov/pubmed/35008407
http://dx.doi.org/10.3390/cancers14010245

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